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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
The effect of partial agonist of serotonin-1A receptor on cognitive functions in animal model of schizophrenia
 Antošová, Eliška ; Valeš, Karel (advisor) ; Telenský, Petr (referee)
Serotoin is a neurotransmitter participating in regulation of many physiologic fuctions. Main serotogenous neurons can be found in nukleus raphe of the brain stem. Nucleus raphe inervates many areas of the brain including the cerebal cortex and hipocampus. These structures are important for controling of higher cognitive functions. 5HT1A receptor is one of many subtypes of serotonin receptors and its activation inhibits iniciating of the action potencials. 5HT1A receptor is expressed presynapticaly as an autorecpetor in nucleus raphe. Activation of 5HT1A receptors decreased the output of the serotonin in the target structures. This key position enables to regulate the serotonin level in the brain. 5HT1A receptor can be found also postsynapticaly as an heteroreceptor in the hippocampus and in the brain cortex, where it affects the output of many other neurotransmitters. Experimental studies indicate that affecting of the 5HT1A function can improve many neuropsychiatric disorders such as schizophrenia, anxiety, depresion and it can also moderate the congitive deficit. It is supposed that the activation of 5HT1A autoreceptors and the inhibition of 5HT1A heteroreceptors can positively affect the cognigtive abilities. It seems that 5TH1A autoreceptors are more sensible for pharmacologic influence. Thus in these...
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